OPA1 and MICOS Regulate mitochondrial crista dynamics and formation
نویسندگان
چکیده
منابع مشابه
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.
Mitochondrial morphology is regulated by the balance between two counteracting mitochondrial processes of fusion and fission. There is significant evidence suggesting a stringent association between morphology and bioenergetics of mitochondria. Morphological alterations in mitochondria are linked to several pathological disorders, including cardiovascular diseases. The consequences of stress-in...
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The dynamic network of mitochondria fragments under stress allowing the segregation of damaged mitochondria and, in case of persistent damage, their selective removal by mitophagy. Mitochondrial fragmentation upon depolarisation of mitochondria is brought about by the degradation of central components of the mitochondrial fusion machinery. The OMA1 peptidase mediates the degradation of long iso...
متن کاملsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation
Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase. Dynamic membrane remodeling allows mitochondria to adapt to changing physiological requirements. The mitochondrial contact site and cristae organi...
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McVean, G.A., Gabriel, S.B., Reich, D., Donnelly, P., et al. (2005). Comparison of fine-scale recombination rates in humans and chimpanzees. Science 308, 107–111. 14. Ptak, S.E., Hinds, D.A., Koehler, K., Nickel, B., Patil, N., Ballinger, D.G., Przeworski, M., Frazer, K.A., and Paabo, S. (2005). Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet. 37, 429–434. 15...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2020
ISSN: 2041-4889
DOI: 10.1038/s41419-020-03152-y